THE ROLE OF INFLAMMATORY MEDIATOR GENES IN THE DEVELOPMENT AND CLINICAL COURSE OF ULCERATIVE COLITIS

Authors

  • Nurmukhamedova N.S. Tashkent Medical Academy, Tashkent, Republic of Uzbekistan Author

Keywords:

In clinical practice, variable therapeutic responses and the progression to severe, corticosteroid-refractory forms are closely associated with allelic polymorphisms in genes encoding inflammatory mediators.

Abstract

Background. Ulcerative colitis (UC) is a multifactorial autoimmune pathology characterized by chronic, diffuse erosive-ulcerative mucosal inflammation of the large intestine. Disruption of epithelial barrier integrity and hyperproduction of pro-inflammatory cytokines resulting from mucosal immunoregulatory imbalance play a central role in the pathogenesis of the disease. 

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Published

2026-10-08

Issue

Vol. 3 No. 9 (2026): Introduction of new innovative technologies in education of pedagogy and psychology

Section

Articles