TNF-α GENE POLYMORPHISMS AND IL-1β/IL-10 CYTOKINE BALANCE AS PREDICTORS OF CLINICAL COURSE IN NONSPECIFIC ULCERATIVE COLITIS

Khamraev A.A., Nurmuxamedova N.S.

TNF-α GENE POLYMORPHISMS AND IL-1β/IL-10 CYTOKINE BALANCE AS PREDICTORS OF CLINICAL COURSE IN NONSPECIFIC ULCERATIVE COLITIS

Authors

Khamraev A.A., Nurmuxamedova N.S. Department of Internal Medicine and Endocrinology, Tashkent State Medical University, Tashkent, Republic of Uzbekistan Author

Abstract

Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disease of the colon characterized by a heterogeneous clinical course. Genetic susceptibility and dysregulated cytokine signalling, particularly involving TNF-α, IL-1β and IL-10, are considered key contributors to disease onset, activity and phenotypic diversity; however, their combined diagnostic and prognostic value remains insufficiently defined.