KI-67 AS A MARKER OF TUMOR CELL PROLIFERATIVE ACTIVITY

Abstract

Ki-67 protein, also known as MKI-67, is a cellular marker of proliferation widely used in immunohistochemistry. It is closely associated with cell proliferation and serves as an important indicator of the growth activity of tumor cells. During interphase, the Ki-67 antigen is detected only in the cell nucleus, whereas during mitosis most of the protein relocates to the surface of chromosomes.